Norditropin Nordiflex Dosage/Direction for Use

Norditropin should only be prescribed by doctors with special knowledge of the therapeutic indication of use.
Posology: The dosage is individual and must always be adjusted in accordance with the individual's clinical and biochemical response to therapy.
Generally recommended dosages: Paediatric population: Growth hormone deficiency: 0.025 - 0.035 mg/kg/day or 0.7 - 1.0 mg/m²/day.
When GHD persists after growth completion, growth hormone treatment should be continued to achieve full somatic adult development including lean body mass and bone mineral accrual (for guidance on dosing, see Replacement therapy in adults as follows).
Turner syndrome: 0.045 - 0.067 mg/kg/day or 1.3 - 2.0 mg/m²/day.
Chronic renal disease: 0.050 mg/kg/day or 1.4 mg/m²/day (see Precautions).
Small for Gestational Age: 0.033 to 0.067 mg/kg/day or 1.0 to 2.0 mg/m²/day.
Adult population: Replacement therapy in adults: The dosage must be adjusted to the need of the individual patient.
In patients with childhood onset GHD, the recommended dose to restart is 0.2 - 0.5 mg/day with subsequent dose adjustment on the basis of IGF-1 concentration determination.
In patients with adult onset GHD, it is recommended to start treatment with a low dose: 0.1 - 0.3 mg/day. It is recommended to increase the dosage gradually at monthly intervals based on the clinical response and the patient's experience of adverse events. Serum IGF-1 can be used as guidance for the dose titration. Women may require higher doses than men, with men showing an increasing IGF-1 sensitivity over time. This means that there is a risk that women, especially those on oral oestrogen replacement, are undertreated while men are overtreated.
Dose requirements decline with age. Maintenance dosages vary considerably from person to person, but seldom exceed 1.0 mg/day.
Method of administration: Generally, daily subcutaneous administration in the evening is recommended. The injection site should be varied to prevent lipoatrophy.